
Such great news. Such fab news! Holly and Hamilton are finally in their forever home, together, happy and safe.
Congratulation guys. Can't wait to meet your lucky humans at the bash. Hamilton, don't forget, we have a date.
My heart is happy.
'vie
ScienceDaily (Mar. 24, 2009) — Diagnosed with an extremely aggressive form of cancer called anal sac adenocarcinoma, Oscar's future seemed bleak. Bedridden and unresponsive to chemotherapy or radiation, he would be lucky to survive three months. But thanks to an innovative new drug treatment, Oscar's cancer receded and he was walking again within two weeks.
"We are one of the few research groups that is offering to treat dogs with cancer that otherwise have no hope," Bauer said. "With no other options available, most people in this situation opt to euthanize so that their pets don't go through the pain of disease and trauma of surgery."
About six million dogs are diagnosed with cancer each year in the United States. According to the National Cancer Institute (NCI), pets with cancer provide a win-win opportunity for cancer researchers. Scientists can study new cancer treatments in animals other than lab mice. And pets get access to new treatments that provide hope and in instances like NO-Cbl, additional time.
Bauer put it this way: "The beauty of using a dog or a cat to test a cancer drug is two-fold. First, the animal can get the benefit of the most up-to-date drug in cancer medicine. Second, the NCI gets data on pets that are exposed to the same environmental factors their owners are. They breathe the same polluted air and drink the same polluted water that you and I do every day. If you can find an agent to treat cancer that occurs in a dog with success, there is a higher likelihood that you can take that to the human population and have a much higher response rate than with mice."
Although NO-Cbl has been used in only a few dogs, daily treatments have led to promising results in each case. "In all four dogs, there has been a significant reduction in tumor size without any toxic side effects or discomfort," says Bauer.
Oscar was the first success story. Since then, Bauer has treated two other dogs. A six-year old golden retriever named Buddy was unable to walk due to a spinal tumor pinching essential nerves leading to his right hind leg. After nine months of daily NO-Cbl treatment, Buddy's tumor shrank by 40 percent and he was going on two mile walks. A 13-year-old female Giant Schnauzer with inoperable thyroid carcinoma also showed tumor reductions of 77 percent in less than 10 weeks.
"Our case studies demonstrate anti-tumor efficacy with limited toxicity to normal tissues," Bauer added. "NO-Cbl sensitizes multidrug-resistant cancer cells to the antitumor effects of several different drugs, so it may be valuable when utilized in combination regimes," he added.
The drug targets cancer cells with "biological Trojan horse technology." Cells have receptors for vitamin B12 on their outer surface. The receptors serve as docking ports where molecules of the vitamin, essential for cells to divide and multiply, attach and then enter the cell. In order to divide at their abnormally rapid pace, cancer cells grow extra B12 receptors — 100 times more than normal cancer cells. Scientists have been trying since the 1950s to exploit that vulnerability and make B12-based drugs that attach to the receptors, sneak into the cell, and deliver a knock-out dose of medication.
Bauer and his colleagues from the Cleveland Clinic attached nitric oxide (NO) molecules to vitamin B12. NO kills cancer cells. The B12 acts as the Trojan horse, easily slipping into cancer cells. The subsequent release of toxic NO kills the cancer cells from within.
The team's goal is to successfully treat 10 dogs with NO-Cbl and slingshot the drug into human use as soon as possible. Because of the genetic similarity between dogs and humans, Bauer says his approach should have a much better chance of getting through the FDA's strict drug approval chain.
But Bauer stresses he wants to get the NO-Cbl dog treatment approved, as well. "I'm committed to the animals, and my goal would be to do a dual clinical trial, Phase One human and Phase One dog," says Bauer.
Oscar is still alive and well. Today, Bauer is treating another Golden Retriever named Haley with a spinal tumor.
"This is one of the most rewarding things I've ever done in my life," says Bauer, the owner of a two-year old Beagle. "It gets boring working in the lab, but to see the fruits of your labor in a positive outcome like this and to know you're responsible in some small way, that's pretty cool."
By Rebecca Morelle Science reporter, BBC News |
A pink baby elephant has been caught on camera in Botswana.
A wildlife cameraman took pictures of the calf when he spotted it among a herd of about 80 elephants in the Okavango Delta.
Experts believe it is probably an albino, which is an extremely rare phenomenon in African elephants.
They are unsure of its chances of long-term survival - the blazing African sunlight may cause blindness and skin problems for the calf.
Mike Holding, who spotted the baby while filming for a BBC wildlife programme, said: "We only saw it for a couple of minutes as the herd crossed the river.
"This was a really exciting moment for everyone in camp. We knew it was a rare sighting - no-one could believe their eyes."
Albino elephants are not usually white, but instead they have more of a reddish-brown or pink hue.
While albinism is thought to be fairly common in Asian elephants, it is much less common in the larger African species.
Ecologist Dr Mike Chase, who runs conservation charity Elephants Without Borders, said: "I have only come across three references to albino calves, which have occurred in Kruger National Park in South Africa.
![]() | ![]() ![]() ![]() Dr Mike Chase, Elephants Without Borders |
"This is probably the first documented sighting of an albino elephant in northern Botswana.
"We have been studying elephants in the region for nearly 10 years now, and this is the first documented evidence of an albino calf that I have come across."
He said that the condition might make it difficult for the calf to survive into adulthood.
"What happens to these young albino calves remains a mystery," said Dr Chase.
"Surviving this very rare phenomenon is very difficult in the harsh African bush. The glaring sun may cause blindness and skin problems."
However, he told BBC News that there might be a ray of hope for the pink calf as it already seemed to be learning to adapt to its condition.
![]() | ![]() ![]() Dr Mike Chase, Elephants Without Borders |
Dr Chase explained: "Because this elephant calf was sighted in the Okavango Delta, he may have a greater chance of survival. He can seek refuge under the large trees and cake himself in a thick mud, which will protect him from the Sun.
"Already the two-to-three-month-old calf seems to be walking in the shade of its mother.
"This behaviour suggests it is aware of its susceptibility to the harsh African sun, and adapted a unique behaviour to improve its chances of survival."
He added: "I have learned that elephants are highly adaptable, intelligent and masters of survival."
Petland Faces Class Action Lawsuit for Peddling Unhealthy Puppy Mill.
Dogs in at Least 20 States
March 17, 2009
PHOENIX — Members of The Humane Society of the United States and other consumers filed a class action lawsuit alleging that Petland, Inc. and the Hunte Corporation are conspiring to sell unhealthy puppy mill puppies to unsuspecting consumers in numerous states. Petland is the nation's largest chain of pet stores that sells puppy mill dogs and Hunte is one of the country's largest distributors of factory-produced puppies.
The lawsuit, filed in federal district court in Phoenix late Monday, alleges that Petland and Hunte violated federal law and numerous state consumer protection laws by misleading thousands of consumers across the country into believing that the puppies sold in Petland stores are healthy and come from high-quality breeders. Many of the puppies sold by Petland come either directly from puppy mills or puppy brokers such as Hunte, which operates as a middleman between the mills and Petland's retail stores.
"Unscrupulous dog dealers like Petland and Hunte reap massive profits by pushing unhealthy puppies on well-intentioned dog-lovers who would never knowingly buy a puppy mill dog," said Jonathan Lovvorn, vice president & chief counsel for Animal Protection Litigation at The HSUS. "Families often bear the great expense of veterinary treatment for sick and unhealthy dogs, or the terrible anguish of losing a beloved family pet.
This industry has been systematically lying to consumers for years about the source of the dogs they sell, and it's long past time for a reckoning.."
The class action lawsuit is the result of many months of investigative and legal research, and comes after an eight-month investigation into Petland stores by The HSUS (http://www.hsus.org/pets/pets_related_news_and_events/petland_puppy_mill_112008.html <http://www.hsus.org/pets/pets_related_news_and_events/petland_puppy_mill_112008.html>;) that demonstrated a direct link between multiple Petland stores and unscrupulous puppy mills. Numerous other reports have also surfaced of Petland's allegedly deceptive sales practices, including the marketing and sale of puppies with life-threatening genetic defects and highly contagious parasitic and viral infections.
The 34-page complaint includes numerous examples of sick or dying puppies that Petland sold, including:
* Mainerd, a Boston terrier, was diagnosed with a congenital spinal condition. Some of her vertebrae have not formed completely while others have fused together causing tissue to grow underneath along with possible nerve damage. Mainerd is now receiving steroid treatments for her ailments and may require expensive surgery. * Minchy, a miniature pinscher, was sold by Petland at 10 weeks old. He was immediately diagnosed with coccidian, an intestinal parasite that causes diarrhea and weight loss. Minchy was also diagnosed with an inherited disorder, Progressive Retinal Atrophy, which will ultimately lead to permanent blindness.
* Tucker was sold at 4 months old. The bloodhound puppy experienced severe separation anxiety and various health problems before developing orbital cancer at only 7 months of age.
* Patrick, a Pomeranian puppy, was sold at three months old. He suffered from diarrhea and vomiting shortly after arriving at his new home. At 11 months old, Patrick was diagnosed with a genetic disorder, dual luxating
patellas, which will require expensive surgery on both of his knees to correct.
Puppy mills are mass breeding operations where the health of dogs is disregarded in order to maintain a low overhead and maximize profits.
The dogs are often kept in wire cages, stacked on top of each other, with no exercise, socialization, veterinary care, or loving human interaction. They are treated not like family pets, but like a cash crop. Petland denies it supports these substandard breeding facilities, and claims to follow "Humane Care Guidelines" developed in conjunction with the USDA. However, USDA recently informed HSUS in writing that it has no record of any such guidelines.
The class plaintiffs are being represented in the case by Saltz Mongeluzzi Barrett & Bendesky, PC; Hagens Berman Sobol Shapiro, LLC; Garen Meguerian, Esq. and lawyers in The HSUS's Animal Protection Litigation section. The suit requests a jury trial on behalf of the consumer class plaintiffs, and seeks reimbursement of the puppies' purchase price along with compensation for all related monetary damages
for the class members.
To learn more about puppy mills, visit humanesociety.org/stoppuppymills.
reprinted in full.